Dosing & Administration for Patients With EPI due to Chronic Pancreatitis or Pancreatectomy

Getting started with CREON 36K

Specific dosing for patients with EPI due to chronic pancreatitis (CP) or pancreatectomy

CREON 36K Lipase Unit Capsule Example Dosing

Two CREON 36K lipase unit capsules

during
meals

One CREON 36K lipase unit capsule

during
snacks

Capsules shown are not actual size and do not represent the exact color shade.

CREON 36,000 may not be appropriate for all patients. CREON is also available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.

  • CP/Pancreatectomy Study: Patients received either placebo or 72,000 units of lipase per main meal (3 main meals) and 36,000 units per snack (2 snacks) while consuming ≥100 g of fat per day.1,2
  • Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.1
  • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (≥4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.1

CREON should be taken during every meal and snack1

Meals and snacks are for illustrative purposes only.

CREON Dosing Tips

Hear from gastroenterologist Shahab Mehdizadeh, MD, as he shares tips for dosing CREON in patients with EPI due to CP or pancreatectomy.

Watch video

When adjusting the dosage, prescribe a dose within the recommended range based on patient weight1†

Patient weight

110 lb 49.9 kg

Minimum per-meal dose

36,000
lipase units

Maximum per-meal dose

108,000
lipase units

Patient weight

130 lb 59.0 kg

36,000
lipase units

144,000
lipase units

Patient weight

160 lb 72.6 kg

72,000
lipase units

180,000
lipase units

Patient weight

200 lb 90.7 kg

72,000
lipase units

216,000
lipase units

Patient weight

230 lb 104.3 kg

72,000
lipase units

252,000
lipase units

Based on guidelines established by the Cystic Fibrosis Foundation (CFF).

This chart is intended to be a guide for the CREON 36,000 lipase unit dosing option. CREON capsules represent nearest capsule count within the recommended dosing range.

Capsules shown are not actual size and do not represent the exact color shade. For illustrative purposes only.

CREON 36,000 may not be appropriate for all patients. CREON is also available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.1

Dosing and administration considerations

  • CREON should always be taken with food. CREON should not be crushed or chewed.
  • If a CREON dose is missed, the next dose should be taken with the next meal. Doses should not be doubled.
  • Total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.
The CFF Guidelines also provide a dietary fat-based maximum lipase dose of less than 4,000 units per g of fat ingested per day.

Instructions for patients who have a hard time swallowing capsules

If your patients have problems swallowing CREON capsules, you can guide them with the following steps:

Hold the capsule upright so that you can read the word CREON on the capsule.

Carefully twist off the top portion of the capsule over the food you plan to eat.

Sprinkle the contents of the capsule on a small amount of room temperature acidic food such as applesauce. Ask your doctor about other foods you can mix with CREON. Do not crush the contents of the capsules.

Swallow the CREON soft food mixture right away without chewing and drink enough water or juice to make sure the contents of the capsules are swallowed completely. Do not store CREON that is mixed with food.

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