Determine your patient’s dose
The dosing guide calculates an appropriate dose or dosing range for each patient based on guidelines established by the Cystic Fibrosis Foundation (CFF).1
CREON
Per-meal Dosing Guide
CREON is indicated for the treatment of Exocrine Pancreatic Insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.
Select your patient’s
UNDERLYING CONDITION
Select your patient's
AGE
Select your patient's
WEIGHT
Recommended CREON
Dosing Range
Per-meal Lipase Unit Range
Minimum
Maximum
CREON Dosing Strength
Number of Capsules
Per meal
Per snack
This is intended for informational use only. Number of CREON capsules represents pill count within recommended range.
The recommended CREON dose for adults with chronic pancreatitis or pancreatectomy is based on one clinical trial in which patients received CREON at a dose of 72,000 lipase units per meal while consuming at least 100 g of fat per day. Lower starting doses recommended in the literature are consistent with the 500 lipase units/kg of body weight per meal lowest starting dose recommended for adults in the Cystic Fibrosis Foundation Consensus Conferences Guidelines.
Number of Capsules
1
Per 120 mL of formula or per breastfeeding
Although the Conferences recommend doses of 2,000 to 4,000 lipase units in infants up to 12 months, CREON is available in a 3,000 lipase unit capsule. Therefore, the recommended dose of CREON in infants up to 12 months is 3,000 lipase units per 120 mL formula or per breastfeeding.
Rx Script Example
ePrescribing Reminder
Rx Script Example
CREON (pancrelipase)
Lipase Units/120 mL
of formula or per breastfeeding
30-day total:
To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.
This is intended for informational use only and shows the minimum appropriate recommended dosing for the patient criteria specified. The total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated. CREON dosage should be individualized and adjusted based on the clinical symptoms, degree of steatorrhea present, and the fat content of the diet.
ePrescribing Reminder
When using e-prescribing systems, please make sure to specify the number of capsules that should be taken per meal and per snack in the notes area.
Example notes:
Lipase Units/120 mL of formula or per breastfeeding.
To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.
CREON should be taken during every meal and snack1
Meals and snacks are for illustrative purposes only.
After starting your patient on CREON, follow up as early as 7 days to assess the need for a dose adjustment1*
CREON dosage should be individualized and adjusted based on1:
Safety and dosing considerations
- CREON should be initiated at the lowest recommended dose based on the patient’s weight.
- CREON should always be taken with food. CREON should not be crushed or chewed.
- Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.
- Total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.†
- Fibrosing colonopathy has been reported in patients with cystic fibrosis taking high-dose pancreatic enzyme replacement therapy.
†The CFF Guidelines also provide a dietary fat-based maximum lipase dose of less than 4,000 units per g of fat ingested per day.
CREON patient support programs
offer financial, multivitamin, and
educational support
Programs
