Diagnosing Exocrine
Pancreatic Insufficiency (EPI)

EPI is largely a clinical diagnosis2

Look for symptoms and underlying conditions

EPI should be suspected when patients present with one or more symptoms, especially if they have an underlying condition.2


Get the details

Signs and symptoms of EPI are not always evident3:

  • Patients may modify their diet to help address symptoms
  • It is important to look at a patient’s medical history

Since patients may be hesitant to share all of their GI symptoms, a detailed and open conversation may help you obtain a diagnosis.

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Discussion Guide

Tests can help confirm a diagnosis of EPI

Direct measures of pancreatic function include:

  • Secretin-pancreozymin stimulation tests performed by gastroenterologists at specialized centers2

Indirect measures of pancreatic function include:

  • 72-hour fecal fat collection, the standard for indirect testing2,4
  • Qualitative fecal fat analysis by microscopic examination of random stool samples used for screening4
  • Fecal elastase concentration (FEC) to measure the concentration of pancreatic enzyme elastase5

An abnormal secretin test or fecal elastase <200 µg/g may confirm an EPI diagnosis.2,5

How to Manage EPI
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Understand the impact that EPI can have

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Symptoms of EPI are not always evident

Recognize the Signs
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What should a treatment plan for EPI include?

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