EPI is largely a clinical diagnosis

Look for signs and symptoms and have an open discussion with patients

Patients may present with signs and symptoms similar to those of other GI conditions.Any one or combination of the following symptoms could mean EPI3:


Abdominal pain



Unexplained weight loss


It’s important to discuss the frequency and severity of symptoms and assess clinical features, such as symptom onset and stool quality.4

Consider underlying conditions and surgical procedures

Remember to discuss underlying conditions and procedures that can lead to EPI2,5-11:

  • Chronic pancreatitis
  • Cystic fibrosis
  • Pancreatectomy
  • Pancreatic cancer

Other underlying conditions and procedures in which EPI has been reported include12-16:

  • Acute pancreatitis
  • Celiac disease
  • Crohn’s disease
  • Gastric resection/bypass
  • Type 1 diabetes
  • Type 2 diabetes

Monitor patients with underlying conditions and procedures for symptoms that can indicate EPI.4

Testing can help confirm a clinical diagnosis

  • Tests such as fecal elastase-1 (FE-1), qualitative fecal fat analysis, or quantitative fecal fat analysis can help confirm an EPI diagnosis17
  • Despite available tests, EPI is largely a clinical diagnosis18
  • There is no single convenient, sensitive, and specific diagnostic test for EPI17,19

Code directly for EPI using ICD-10 code K86.8120

Benefits of using ICD-10 code include:

  • Coding directly for EPI20
  • Measuring patient outcomes21
  • Increasing efficiency in the exchange of clinical information21
  • Improving diagnostic and epidemiologic data available21

ICD-10 code


Review insights that shed light on some of the difficulties associated with diagnosing EPI.

Tools and resources are available to help you diagnose and manage EPI.

*Steatorrhea: ≥7 g of fecal fat per day while consuming 100 g of dietary fat per day in the context of a 72-hour stool test.18

EPI = exocrine pancreatic insufficiency.