EPI management

Consider the following components in your comprehensive EPI management plan

Pancreatic enzyme replacement therapy (PERT)—the standard of care for EPI treatment2,3

  • PERTs replace pancreatic enzymes lipase, protease, and amylase2
  • PERTs help break down fats, proteins, and carbohydrates so they can be absorbed within the intestines and into the bloodstream4

Vitamin supplementation5

  • Fat-soluble vitamins A, D, E, and K6-10:
    • Vitamins A and E are antioxidants and may protect against free radicals
    • Vitamin D aids in calcium absorption and subsequent bone growth
    • Vitamin K is necessary for the clotting of blood

Lifestyle modifications11

  • Eating a well-balanced diet
  • Avoiding or limiting alcohol intake
  • Smoking cessation

PERT dosing and administration reminders

Remember to take the following into account when determining an appropriate PERT dosage and writing a prescription. It’s important to discuss these dosing reminders with patients so that they understand why their specific dose was chosen and when to take it.

When dosing PERTs, consider patient weight and adjust dose based on clinical symptoms, steatorrhea, and dietary fat content.12,13

PERT capsules should always be taken with meals and snacks.5

EPI = exocrine pancreatic insufficiency.