Mechanism of Action

See how CREON works

CREON is a pancrelipase that replaces enzymes that are normally secreted by the pancreas. CREON is
formulated to deliver enzymes to the duodenum where the pH is the most conducive to enzymatic activity.
Instruct your patients to always take CREON with food. CREON should not be crushed or chewed.1

CREON should be taken during meals or snacks.

Along with food, the CREON capsules enter the stomach.

Capsule releases enteric-coated spheres sized between 0.7 and 1.6 mm in diameter.

Enteric coating allows the spheres to travel beyond the low pH of the stomach through the pylorus, releasing enzymes into the duodenum and the small intestine when the pH is ≥5.5.

CREON enteric-coated spheres dissolve in the duodenum and the small intestine, releasing pancreatic enzymes to mix with food.

In the duodenum and the small intestine, these enzymes work to break down fats, proteins, and carbohydrates in food.

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Determine an appropriate per-meal dose for your patients

Use Dosing Guide
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CREON offers a wide range of dosing strengths

See Dosing Strengths
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CREON patient support programs offer financial, multivitamin, and educational support

See Patient Support