Helping adult patients get started with CREON

CREON has multiple dosage strengths to help meet your adult patients' lipase needs

CREON 36K or 24K capsules may be an appropriate strength for many adult patients with EPI

36,000

lipase units

24,000

lipase units

12,000

lipase units

6,000

lipase units

3,000

lipase units

Capsules shown are not actual size and do not represent the exact color shade.
For illustrative purposes only. The active ingredient in CREON evaluated in clinical trials is lipase.

Starting your adult patients on CREON and setting expectations to manage their EPI

1

Inform, initiate, and instruct1

  • Inform patients that EPI is a chronic condition requiring long-term management and that their dosage may need to be adjusted over time
  • Use either an actual body weight or fat ingestion-based dosing scheme
  • Start at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet
  • Instruct patients that CREON should be taken with every meal and snack, and that capsules should not be crushed or chewed

Establish your patient’s dose with the CREON dosing calculator and review additional dosing guidelines

Dosing calculator
Dosing for EPI
Dosing in adult EPI patients with CP/PY

2

Follow up and individualize1

  • Check to confirm patients are taking CREON as prescribed
  • If signs and symptoms of malabsorption persist, increase the dosage
    • Titrate to either 2,500 lipase units/kg/meal, 10,000 lipase units/kg/day, or 4,000 lipase units/gram of fat ingested/day
  • Follow up with patient as early as 5-7 days after starting CREON to assess the need for dose adjustment*

 

Individualize your patient’s CREON dosage through these factors1:

Clinical signs and symptoms

Degree of steatorrhea present

Dietary fat content

Changes in dosage may require an adjustment period of several days.

*In clinical studies, improvement in fat absorption after treatment with CREON was assessed as early as 5‑7 days.1

CREON Treatment Tracker

Encourage patients to use the Treatment Tracker to record their symptoms, dietary habits, and dosing/administration routines and share this information with you at their next follow-up appointment.

Download now

Safety and dosing considerations1

  • Fibrosing colonopathy has been reported following treatment with pancreatic enzyme products. Do not exceed the recommended dosage of 2,500 lipase units/kg/meal, or 10,000 lipase units/kg/day, or 4,000 lipase units/g fat ingested/day in adult and pediatric patients greater than 12 months of age without further investigation.
  • Start at the lowest recommended dosage and individualize the dosage based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.
  • CREON should not be crushed, chewed, or retained in the mouth. CREON should always be taken with food.
  • If a dose is missed, the next dose should be taken with the next meal or snack. With each snack, administer approximately half the prescribed CREON dose for a meal.
  • CREON should be kept in a dry place and in the original container.

EPI = exocrine pancreatic insufficiency.

Full safety profile